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As previously mentioned, whilst low to moderate physiological levels of ROS are beneficial for several processes of wound healing pathophysiology, excess ROS can be deleterious

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48 Conditions such as high-fat diet exposure or oxidative stress result in NAD + depletion and reduced SIRT1 activity

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The hydration process was carried out using 10 ml phosphate buffer (PH 7.4) contains glutathione in amount adjusted to obtain 2% final concentration

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